Structure-relaxivity mechanism of an ultrasmall ferrite nanoparticle T-1 MR contrast agent: The impact of dopants controlled crystalline core and surface disordered shell

Miao, Yuqing; Zhang, Huan; Cai, Jing; Chen, Yimin; Ma, Huijun; Zhang, Shuo; Yi, Jia Bao; Liu, Xiaoli; Bay, Boon-Huat; Guo, Yingkun; Zhou, Xin; Gu, Ning; Fan, Haiming

Title: Structure-relaxivity mechanism of an ultrasmall ferrite nanoparticle T-1 MR contrast agent: The impact of dopants controlled crystalline core and surface disordered shell
Creator: Miao, Yuqing; Zhang, Huan; Cai, Jing; Chen, Yimin; Ma, Huijun; Zhang, Shuo; Yi, Jia Bao; Liu, Xiaoli; Bay, Boon-Huat; Guo, Yingkun; Zhou, Xin; Gu, Ning; Fan, Haiming
Relation: ARC.FT16010020.FT16010020
Relation: Nano Letters Vol. 21, Issue 2, p. 1115-1123
Publisher Link: http://dx.doi.org/10.1021/acs.nanolett.0c04574
Publisher: American Chemical Society
Resource Type: journal article
Date: 2021
Description: Ultrasmall ferrite nanoparticles (UFNPs) have emerged as powerful magnetic resonance imaging (MRI) T₁ nanoprobe for noninvasive visualization of biological events. However, the structure–relaxivity relationship and regulatory mechanism of UFNPs remain elusive. Herein, we developed chemically engineered 3.8 nm ZnxFe₃–xO4@ZnxMnyFe_3–x–x–yO₄ (denoted as Zn_xF@Zn₄Mn₄F) nanoparticles with precise dopants control in both crystalline core and disordered shell as a model system to assess the impact of dopants on the relaxometric properties of UFNPs. It is determined that the core–shell dopant architecture allows the optimal tuning of r1 relaxivity for Z_0.40.4F@Zn_0.40.4Mn_0.2F up to 20.22 mM^–1 s^–1, which is 5.2-fold and 6.5-fold larger than that of the original UFNPs and the clinically used Gd-DTPA. Moreover, the high-performing UFNPs nanoprobe, when conjugated with a targeting moiety AMD3100, enables the in vivo MRI detection of small lung metastasis with greatly enhanced sensitivity. Our results pave the way toward the chemical design of ultrasensitive T₁ nanoprobe for advanced molecular imaging.
Subject: dopants controlled ultrasmall ferrite nanoparticles; magnetic resonance imaging; T₁; contrast agent
Identifier: http://hdl.handle.net/1959.13/1435735
Identifier: uon:39803
Identifier: ISSN:1530-6984
Language: eng
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